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KMID : 0363320040250010106
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Journal of Korean Oriental Internal Medicine
2004 Volume.25 No. 1 p.106 ~ p.118
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A Study on Antimutagenic acitivities of from Puerariae Flos Extracts
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Jeong Young-Jae
Kim Mi-Rang
Seo Un-Kyo
Jung Ji-Chun
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Abstract
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Antigenotoxicity test (SOS chromotest), antimutagenecity test (Ames test), and antioxidant test (NBT method and xanthine-xanthine oxidase method) were carried out using water-soluble and methanolic extracts from Puerariae Flos. Against the mutagens MNNG and NQO, antigenotoxic activity of methanolic extracts were much more effective than that of water-soluble ones. When the methanolic extract was added to the certain concentration (100{mu}{ell}/tube), antigenotoxic acivity against the mutagen MNNG was enhanced. Contrary to the water-soluble extract, the methanolic extract showed high antigenotoxicity against the mutagen NQO with increment of the extract. Against the mutagen MNNG with Ames test, antimutagenic activity of the methanolic extract at 300{mu}{ell}/tube was 96 as an inhibition ratio of revertant forming CFU/plate. The antioxidant activity of water-soluble extract was comparatively higher than that of the methanolic one.
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KEYWORD
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SOS chromotest, Ames test, NBT method and xanthine-xanthine oxidase method, Puerariae Flos, MNNG, NQO
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